The river-crossing project at Shanghai West Yangtze River Road is dual six-lane scale adopting large slurry shield of which the outer diameter is 15.43 m for the tunneling construction. Because the distance between the large diameter tunnel structures and pile-foundation is about 1 m, it is not in accordance with the relevant regulations related to the protection of engineering. So, it is necessary to study the influence of construction of side-crossing shield tunnel on adjacent pile foundation and the reinforcement effect of protection measures. In this paper, numerical simulation and field monitoring are employed to study the construction effect based on the ground loss, metro jet system(MJS) reinforcement of piles and different scopes of consolidation are taken into account. A safe and economical protect measure is presented by analyzing the deformation and bearing capacity of pile foundation. Finally, it is showt that the field monitoring data agree well with the numerical results. Therefore, the accuracy and rationality of the numerical simulation method is validated.