Combined with a high cutting rock slope near a 220 kV substation, the parameters of the anchors are analyzed based on the limit equilibrium method and numerical method. The design parameters are optimized by comparative analysis of the slope stability results that are calculated by setting different angles and lengths of the anchors. The anchor reinforcement effect is evaluated by surface displacement monitoring, deep ground displacement monitoring and stress monitoring of the anchors. The results show that: (1) With the increase of anchorage angle, the safety factor increases at beginning and then decreases; so there exists an optimum anchor angle. 22°for this project. (2) The anchors in the lower part of slopes exhibit larger axial force; so it is important to focus more on the design parameters of anchors in the lower part of slopes. If the slope safety factor could not satisfy the design requirement, increase the cross-section size or length of the anchors in the lower part of slopes as appropriate. (3) The length inequality design of the anchors is suggested. The anchor length shall be determined by measuring the distance between the slip surface and slope surface at first; then check the calculation results by the limit equilibrium method. (4) The in site monitoring results show that the optimization design of anchors achieves relatively high performance and good economic benefits.