Under the action of earthquake, the deformation and failure mode of the deposit slope depends on many factors. To study the influence of the inclination of slope surface and rock-soil boundary on the dynamic response of the deposit slope, a model test using a horizontal shaking table was conducted to simulate the failure process and dynamic response of the deposit slope under different inclination conditions. The results show that the failure mode of the deposit slope was controlled by both slope surface and rock-soil boundary. When the dip angle of the rock-soil boundary was in a certain extent (less than 20°), only local collapse in the slope occurred. As the dip angle of the rock-soil boundary increased, the failure mode of the deposit slope gradually turned from local collapse to entire sliding. Moreover, the inclination of slope surface controlled the extent of collapse.