By using of the experimental system of advanced MTS and INSTRON rigid servo-controlled testing machine, the destructive energy dissipation test under routine triaxial compression, dynamic and static unconfined uniaxial compression condition of backfills with different cement-sand ratios in the special large-sized stope were made; all kinds of correlative mechanical parameters, full curves of load-displacement and stress-strain were obtained after test. According to the obtained mechanical testing data and the characters of compression experimentation, taking the destructive energy dissipation of single specimen, unit volume, unit weight as check indexes, the different energy dissipation parameters under complicated compression stress conditions of backfill are calculated; the change rules of destructive energy dissipation are analyzed; and the function connection under different loading conditions after statistic regress is set up. It has definite realism meaning to ore pillar mining with safety, maintenance roof’s stabilization of stope and tunnel, geostatic control, prevent ground sink, environment protection so as to break a new path to use the viewpoint of energy dissipation to analyze and study destruction of backfill, which are of a certain instructive importance to mine improving the quality of backfill, including other concrete engineering fields.